GO has been diagnostics and drug discovery. In this paper, we further extensively used to compute the similarity between genes our previous study on gene-disease relationship (details in section 3) [19, 20]. In this work, we use the specifically with the multifunctional genes. We investigate functional annotations of a gene from the Gene Ontology the multifunctional gene-disease relationship based on the Annotation (GOA) databases to compute the shortest published molecular function annotations of genes from distance (path length) between the Molecular Function the Gene Ontology which is the most comprehensive (mf) GO terms annotating the gene.